Hypomethylated blocks in O-exp samples replicated by whole genome bisulfite sequencing. (A-C) Hypomethylation is enriched in blocks. Distribution of high-frequency smoothed methylation values from CpGs with sufficient coverage from WGBS for (A) all CpGs, (B) CpGs in blocks, and (C) CpGs outside of blocks. (D) Examples of blocks identified by WGBS. Shown are smoothed methylation values within blocks identified comparing O-exp and Y-pro epidermis (pink).