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Figure 3 | Genome Biology

Figure 3

From: Denoising perturbation signatures reveal an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine-treated ER+ breast cancer

Figure 3

Validation of the DART-CLQ algorithm.(A) Box plots of predicted activity scores from DART-CLQ of a p53 deactivation signature between normal (N) and cancer (C) tissue in five different tissue types from the Affymetrix study of Yu et al. [18]. Number of samples being compared are given below each box plot. P value is from a Wilcoxon rank sum test. (B) As (A), but for activity scores estimated using DART. (C) As (A), but for activity scores estimated using the Spearman correlation coefficient (SCC). C, cancer; N, normal; SCC, Spearman correlation coefficient.

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