Figure 3

Error rates and detection efficiencies. (a) Illustration of technical errors, including the allelic-dropout rate (ADR) and false positive (FP) error rate. (b) Allelic dropout rates for single-cell experiments using G1/0 and G2/M single cells. (c) Spectrum of FP errors detected in the G2/M single-cell data, with each column representing a single cell. (d) Spectrum of single nucleotide variants detected in the SKN2 population data. (e) Distribution of FP errors on chromosome 7 and 11 that occur in single cells (black) or in two or more cells (red). (f) Detection efficiency for single-nucleotide variants in the G1/0 cells and G2/M cells calculated from the exome sequencing data. (g) Detection efficiency for indels in the G1/0 cells and G2/M cells calculated from single-cell exome sequencing data. Error bars in all panels represent the SEM.