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Figure 5 | Genome Biology

Figure 5

From: Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

Figure 5

Discordant and concordant gene expression in the PI3K-Akt-mTORC1 signaling cascade. A schematic representation of selected components of the PI3K-Akt-mTORC1 signaling cascade based on [59-62]. The shapes indicate age-dependent (ovals) and non-age-dependent (rectangles) expression of pathway components. The colors indicate concordant (blue) and discordant (rose) expression in the aging interval. For each discordant gene, the green square next to the gene name illustrates its activator function in the pathway, while the white arrow in the square indicates the mRNA-protein expression relationship detected in our data. See also Figure S13 in Additional file 1.

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