Figure 4From: 5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer TET2 binds promoters of active genes in cancer cells. (a) Example of TET2 binding profile in HCT116 colorectal cancer cells. (b) TET2 binds close to TSSs and (c, d) primarily at CpG islands within HCP promoters. (e) TET2 bound islands are largely unmethylated and (f, g) associate with active genes.Back to article page