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Figure 3 | Genome Biology

Figure 3

From: FRESCo: finding regions of excess synonymous constraint in diverse viruses

Figure 3

FRESCo recovers known overlapping functional elements in viral genomes. For each virus, a plot of the synonymous substitution rate at 10-codon resolution is shown above; the red tracks below each plot display recovered regions of excess synonymous constraint at window sizes of 1, 5, 10, 20, and 50 codons. We plot regions of excess synonymous constraint in (A) the HBV P gene, which contains overlapping reading frames and regulatory elements, (B) the WNV ORF, which contains overlapping conserved capsid-coding region hairpin and pseudoknot elements, and (C) the poliovirus ORF, which contains multiple experimentally characterized regions of overlapping function. cHP, capsid-coding region hairpin element.

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