Figure 2From: A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies Correcting for statistical inflation due to technical biases. Quantile-Quantile (QQ) plot for the comparison of 36 samples measured in duplicate reveals high statistical inflation before (Genomic Inflation Factor λraw = 12.74; brown points) and after quantile normalisation (λQN = 2.11; green points) due to technical biases. Batch-correction based on control probes removes technical biases and statistical inflation (λCP = 1.01; green points).Back to article page