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Figure 5 | Genome Biology

Figure 5

From: Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

Figure 5

Results of MARINa analyses for Nr3c1/GR in alcohol naive, non-dependent and dependent rats. Both the main stacked-column graph and line graph inset show the total differential activity of Nr3c1/GR across eight regions in the control (alcohol naive), non-dependent, and dependent groups. Differential activity is measured by the normalized enrichment score (NES) in each region, calculated as the differential activity going from alcohol naive to non-dependent and from non-dependent to dependent. Nr3c1/GR is activated in non-dependent alcohol self-administering rats and increases to a lesser extent after the transition to dependence. In regions like the VTA and NAc core, Nr3c1/GR activity increases progressively from alcohol naive to non-dependent to dependent rats, while in the NAc shell, significant Nr3c1/GR activation is seen only after the transition to dependence. The dashed red line in both plots indicate significantly increased differential activity, which corresponds to a total NES of approximately 2.33 and P <0.01.

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