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Figure 4 | Genome Biology

Figure 4

From: Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

Figure 4

Targets of Nr3c1/GR as predicted by the ARACNe-generated transcriptional-interactome. Targets of Nr3c1/GR in the NAc core (A), shell (B), and VTA (C) differentially regulated in the non-dependent vs. dependent signature. Targets of Nr3c1/GR in the CeA (D) in the naive vs. non-dependent signature. For each comparison, the results of GSEA for Nr3c1/GR targets in the corresponding signature are shown on the left and the Nr3c1/GR regulon on the right. In the right panel, the distance between Nr3c1/GR and each target represents the degree of differential expression in the signature. More differentially expressed genes are shown closer to Nr3c1/GR, and less differentially expressed genes are shown further away. Genes in the leading edge of the GSEA analysis are shown in red. These are ones that contribute most significantly to the enrichment of Nr3c1/GR, and are the most strongly regulated targets of Nr3c1/GR. The GSEA panel on the left shows the enrichment plot, NES and associated P value. As with the regulon plot, the genes in the leading edge are also shown in red.

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