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Figure 2 | Genome Biology

Figure 2

From: Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

Figure 2

MARINa results showing candidate MRs driving the alcohol non-dependence vs. dependence differentially expressed gene signature in the core sub-region of the nucleus accumbens (NAc) sorted by their differential activity in alcohol dependence. Each row of the plot shows the result of MARINa for each MR candidate. The P value associated with each MR candidate is shown on the left. The MARINa-predicted differential activity (Act), differential expression (Exp) and are shown on the right in shades of red: higher levels of Exp or Act are indicated in dark red, while lower levels are indicated in light red or pink. The rank of Exp of each MR candidate is also shown on the right side of the plot. The red lines in the middle of the plot indicate ARACNe predicted targets of each MR candidate. The position of each line on the horizontal axis corresponds to its rank in the gene list, which is determined by its differential expression. More differentially expressed genes being shown toward the left, and the less differentially expressed genes displayed toward the right. The identity and differential expression of the ARACNe-predicted targets of each MR candidate can be found in Additional file 3 in the online version of this manuscript.

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