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Table 1 Summary details of the four analysis cohorts

From: DNA methylation age of blood predicts all-cause mortality in later life

 

LBC1921

LBC1936

FHS

NAS

N

446

920

2,635

657

ndeaths

292

106

238

226

Time to death (years)

7.2 (3.5)

4.4 (2.2)

6.0 (1.2)

10.5 (3.3)

Age (years)

79.1 (0.6)

69.5 (0.8)

66.3 (8.9)

72.9 (6.9)

Sex (male)

176 (40%)

465 (51%)

1200 (46%)

657 (100%)

Hannum methylation age (years)

85.0 (5.6)

75.8 (5.0)

68.2 (8.7)

77.6 (6.7)

Hannum Δage (years)

5.9 (5.6)

6.2 (5.1)

1.9 (4.8)

4.6 (4.8)

Hannum median error (years)

5.5

6.4

1.9

4.6

Horvath methylation age (years)

73.7 (6.2)

66.0 (5.8)

65.7 (8.3)

73.5 (7.4)

Horvath Δage (years)

−5.4 (6.3)

−3.6 (5.8)

−0.6 (5.2)

0.6 (5.8)

Horvath median error (years)

6.0

4.7

0.69

3.4

Tissue sample

Whole blood

Whole blood

Whole blood

Buffy coat

Methylation array

Illumina 450 k

Illumina 450 k

Illumina 450 k

Illumina 450 k

  1. FHS: Framingham Heart Study, LBC: Lothian Birth Cohort, NAS: Normative Aging Study.