Figure 3
From: Quantification of cell identity from single-cell gene expression profiles
Marker analysis and identity scores of cells from glioblastoma tumors. (A,B) Spec scores for the glioblastoma markers identified by our algorithm (A) and for the TCGA markers previously published [34] ordered by rank. Tumor subtypes are: CL, classical; MES, mesenchymal; NL, neural; PN, proneural. (C,D) ICI variability (C) and ICI signal (D) for the glioblastoma cells. (E) Number of classified cells in all five tumors as a function of the marker information threshold. Black indicates all classified cells including mixed identities. Gray indicates cells classified as a single identity. Lines indicate number of cells classified in a previously applied algorithm [24]. (F,G) Identity calls for individual cells from each subtype in each of the five tumors, using the algorithm and markers in a previous analysis [24] (F), and using the ICI method with a cumulative information threshold of 110 (G). Each column represents a single cell, and the color-coded bars represent relative identities.