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Table 1 ADAR2-mediated editing events in brain and glioblastoma cells and tissues

From: Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma

Chr

Strand

miRNA

U118

ADAR2

ADAR2 E/A

siADAR2

P -value

Pooled human brain

Human frontal lobe

Glioblastoma

Location in pre-miR

Location in mature miR

Chr9

+

hsa-let-7d*

0.3

2.0

0

0.5

1.61E-10

1.2

0.7

0

66

5

Chr17

-

hsa-mir-22

0

0.1

0

0.1

5.50E-34

0

0

0

67

15

Chr19

-

hsa-mir-24–2*

0.1

16.4

0

7.1

<1E-155

0.8

2.3

ND

18

6

Chr19

-

hsa-mir-27a*

0.1

22.5

0.1

9.8

<1E-155

ND

0

2.6

10

1

Chr21

+

hsa-mir-99a

0.1

13.8

0

6.9

<1E-155

5.0

1.2

0

13

1

Chr11

-

hsa-mir-100

0

0.2

0

0.1

1.22E-145

0

0

0

13

1

Chr3

+

hsa-mir-138–1*

0

0.8

0

0.5

2.57E-35

2.1

0.2

ND

74

12

Chr8

-

hsa-mir-151

0.1

0.3

0

0.2

5.70E-13

0.9

0.6

ND

49

3

Chr11

-

hsa-mir-210

0

0.5

0

0.5

2.31E-11

ND

ND

0

77

12

Chr14

+

hsa-mir-411

0

12.6

0

5.6

4.31E-39

15.3

13.9

3.2

20

5

Chrx

-

hsa-mir-421

0.2

13.8

0.5

9.6

<1E-155

1.8

1.0

0

61

14

Chr9

+

hsa-mir-455

0

14.2

0

5.7

<1E-155

1.2

0.9

0

32

17

Chr17

-

hsa-mir-497

0

26.1

0

16.7

1.73E-155

6.2

0.6

0

25

2

Chrx

-

hsa-mir-503

0

5.9

0

1.7

8.75E-14

ND

ND

0

7

2

Chr7

-

hsa-mir-589*

2.3

9.5

2.2

2.9

1.36E-31

70.0

74.1

0

66

6

Chr19

-

hsa-mir-641

0

17.0

0

8.8

5.83E-116

0

0

0

17

2

Chr19

-

hsa-mir-641

0

3.0

0

0.9

2.45E-14

0

3.6

0

18

3

Chr10

-

hsa-mir-3157*

0

69.4

0

54.5

1.55E-90

ND

ND

0

70

13

Chr16

+

hsa-mir-3176

0

10.9

0

8.2

6.73E-41

ND

ND

0

74

15

  1. A-to-G changes in mature miRNAs isolated from U118 cell lines (untreated, ADAR2, ADAR2 E/A, siADAR2), human brains (pooled and frontal lobe) and glioblastoma. The statistically significant modifications are marked in bold; the edited miRNAs that were not identified in our previous analysis are indicated in italics [23]; miRNAs that are both edited and modulated by ADAR2 are indicated in bold (Additional files 2 and 3).
  2. Editing levels are represented as percentages. ND, not determined (with <10 reads).