Figure 6

ADAR2-mediated editing events within pri-miR-221, pri-miR-222 and pri-miR-21 in HEK293T cells. (a-c) Left: editing sites and percentages of the pri-miR-221 (a), pri-miR-222 (b) and pri-miR-21 (c) are shown. Right: stem-loop structures of each precursor with the edited sites indicated by red and gray circles (the site +187 of pri-miR-221 is not shown in the structure). Adenosines found edited in both ADAR2 HEK293T cells and human brain samples are indicated by red circles. Of note, the site -21 within pri-miR-222 was found highly edited in different human samples, with values increasing from children (4%) to adult (approximately 20%) brain.