Table 5 Overlap between differentially methylated loci in subcutaneous adipose and genes associated with obesity and related traits
Obesity-related trait | GWAS associated genes with at least one DM CpG site | GWAS specific trait(s) | PMID (PubMed IDs) |
|---|---|---|---|
BMI and weight | RASAL2; ADCY3; KCNE4; DGKG; ZNF608; HMGA1; AIF1; TUB; NRXN3; ADCY9; FTO; SEPT9; MC4R; FOXN3 | Body mass index, Weight; Weight loss (gastric bypass surgery) | 17434869, 18454148, 19079260, 19079261, 20935630, 20966902, 22344219, 22344221, 22982992; 23643386; 23583978, 23563607 |
Waist circumference | KCNE4; PPM1H; NRXN3; FTO; MC4R | Waist circumference | 19557197, 20966902 |
Metabolic syndrome | GALNT2; MICB; CAMK2B; TMEM195; TCF7L2; STOML3; LIPC; PKMYT1; FTO; CETP | Metabolic syndrome, Metabolic syndrome (bivariate traits) | 20694148, 21386085, 22399527 |
Metabolic traits | LEPR; ENPEP | Metabolic traits | 19060910, 21886157 |
Blood pressure | CASZ1; CLCN6; CNTN4; MECOM; ENPEP; EBF1; BAT2; MSRA; CACNB2; C10orf107; PLCE1; PLEKHA7; FLJ32810; ATP2B1; PTPN11; ACBD4; PLCD3; MC4R | Blood pressure, Obesity and blood pressure, Diastolic blood pressure, Systolic blood pressure, Hypertension | 17903302, 19430479, 19430483, 21572416, 21909110, 21909115, 22013104 |
Cardiovascular | KLHL29; TCF7L2; CADM1; APOA4; ATP2B1; C12orf51; COL4A1; LIPC; SMAD3; CETP; LCAT; ZFHX3; SMG6; UBE2Z; DNM2; STX16; MRPS6; FLT1; CUX2; PTPN11 | Cardiovascular disease risk factors, coronary heart disease | 17634449, 20838585, 21347282, 21378990, 21943158, 22751097, 23364394 |
Type-2 diabetes | BCL11A; RBMS1; IRS1, MAEA; AKAP2; CAMK1D; TCF7L2; GRK5; TCERG1L; KCNQ1; FTO; CMIP; PALM2; TGFBR3; WISP1; SND1 | Type-2 diabetes, Type 2 diabetes and other traits | 17293876, 17460697, 17463246, 17463248, 17463249, 17554600, 17668382, 18372903, 18711366, 18711367, 19056611, 19404141, 19734900, 20174558, 20418489, 20581827, 20862305, 20864672; 21490949, 21573907, 21799836, 22101970, 22158537, 22456796, 22693455, 22931080, 22961080, 23209189, 23300278; 23532257 |
Blood lipids | MACF1; GALNT2; IRS1; AFF1; ARL15; NPC1L1; DNAH11; PINX1; XKR6; APOA1; APOA4; MYO1H; C12orf51; LIPC; CETP; LCAT; CMIP; MC4R; NCAN | Cholesterol, Cholesterol total, HDL cholesterol, LDL cholesterol, Triglycerides | 17463246, 18193043, 18193044, 19060906, 19060910, 19060911, 19074352, 19359809, 20031538, 20031564, 20066028, 20686565, 20864672, 21909109, 23505323, 20139978 |
Adipose tissue | TP73; KIAA0495; ITPKB; IRS1; LPP; ZNF608; CNTNAP2; MSRA; BICD2; PRICKLE1; RORA; SMAD6; FTO | Adiposity, Visceral adipose tissue/subcutaneous adipose tissue ratio, Subcutaneous adipose tissue, Visceral fat | 19557161, 21706003, 22589738 |
Blood glucose | PROX1; RREB1; TMEM195; TCF7L2; IGF1, FOXN3 | Fasting glucose-related traits (interaction with BMI), Fasting glucose-related traits | 20081858, 22581228 |
Insulin | IRS1; SLC10A6; TCF7L2; TCERG1L; IGF1; ATP10A; LARP6; PCBP3 | Fasting insulin-related traits (interaction with BMI), Insulin-related traits, Fasting insulin-related traits, Proinsulin levels, Insulin resistance/response | 20081858, 21873549, 21901158, 22581228, 22791750 |