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Table 3 Top20 CpG sites in known genes which were most hypermethylated or hypomethylated in subcutaneous adipose

From: An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss

Ilumina probe ID

Gene symbol

Chromosome and map position (build 37)

∆beta

T statistic

P value

cg10838410

IFFO1

12: 6659524

−0.223

−10.2

6.8 × 10−8

cg27631256

TNFSF8

9: 117692745

−0.203

−11.6

1.5 × 10−8

cg21011616

HOXD4

2: 177015992

−0.188

−10.9

3.0 × 10−8

cg22491058

C4BPA

1: 207277466

−0.182

−11.4

1.8 × 10−8

cg07787634

KMO

1: 241715378

−0.177

−10.3

6.7 × 10−8

cg07420362

TRPC2

11: 3647419

−0.176

−10.5

5.1 × 10−8

cg14012082

EPX

17: 56274407

−0.176

−11.9

1.0 × 10−8

cg17518550

C1orf150

1: 247712383

−0.175

−10.3

6.3 × 10−8

cg13053653

HOXD3

2: 177037631

−0.175

−11.0

2.8 × 10−8

cg08400424

ARHGAP26

5: 142357042

−0.172

−10.2

7.7 × 10−8

cg11236746

GLB1

3:33096255

−0.172

−10.5

5.4 × 10−8

cg09359351

HSPBAP1

3:122509111

−0.171

−10.1

8.1 × 10−8

cg14118850

HPCAL1

2:10447890

−0.171

−14.5

7.9 × 10−10

cg20426866

TACC2

10:123923881

−0.170

−12.1

8.6 × 10−9

cg08055663

KCTD5

16:2737356

−0.169

−10.0

9.5 × 10−8

cg08949974

RBM47

4:40632860

−0.167

−10.0

9.0 × 10−8

cg02794695

SLA; TG

8:134072611

−0.166

−10.0

9.2 × 10−8

cg11967765

GNA12

7:2774195

−0.165

−10.0

9.7 × 10−8

cg13453168

PTPRE

10:129845660

−0.165

−11.8

1.2 × 10−8

cg26933869

ALDH4A1

1:1921807

−0.164

−10.0

9.3 × 10−8

cg10111816

CDR2

16: 22384715

0.273

12.1

8.3 × 10−9

cg07852840

SPSB4

3: 140813919

0.273

11.0

2.8 × 10−8

cg17219660

GPR37L1

1: 202091880

0.269

10.7

3.9 × 10−8

cg08344351

CMIP

16: 81507328

0.269

10.0

8.8 × 10−8

cg23753807

ABR

17: 1090291

0.265

13.7

1.7 × 10−9

cg04546573

GULP1

2: 1090291

0.263

10.4

5.8 × 10−8

cg08264805

RUSC1, C1orf104

1: 155291224

0.254

13.8

1.5 × 10−9

cg17691545

SLC10A6

4: 87770586

0.254

11.6

1.4 × 19−8

cg00838040

ATP2C2

16: 84446919

0.244

11.3

2.1 × 10−8

cg13052101

MTL5

11: 68517529

0.239

11.4

1.7 × 10−8

cg10249224

TSSK3; LOC100128071

1: 32828191

0.238

11.3

2.1 × 10−8

cg09869811

NUTF2

16:67897346

0.237

13.4

2.3 × 10−9

cg14563485

ZFP14

19:36860285

0.236

11.5

1.7 × 10−8

cg02363593

DOCK2

5:169123192

0.236

11.8

1.2 × 10−8

cg18573082

PDE7B

6:136425179

0.236

12.4

6.0 × 10−9

cg15174117

CORO2B

15:68913662

0.235

11.8

1.1 × 10−8

cg05939149

PLEKHH2

2:43986106

0.235

10.6

4.4 × 10−8

cg27083087

VGLL4

3:11610239

0.234

10.6

4.4 × 10−8

cg07080653

LNX1

4:54374249

0.233

11.7

1.2 × 10−8

cg17080882

TGFBR3

1:82191625

0.232

10.6

4.8 × 10−8

  1. A positive value for ∆beta indicates hypermethylation before weight loss in comparison to after weight loss, and a negative value indicates hypomethylation.
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Genome Biology

ISSN: 1474-760X

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