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Table 3 Top20 CpG sites in known genes which were most hypermethylated or hypomethylated in subcutaneous adipose

From: An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss

Ilumina probe ID Gene symbol Chromosome and map position (build 37) ∆beta T statistic P value
cg10838410 IFFO1 12: 6659524 −0.223 −10.2 6.8 × 10−8
cg27631256 TNFSF8 9: 117692745 −0.203 −11.6 1.5 × 10−8
cg21011616 HOXD4 2: 177015992 −0.188 −10.9 3.0 × 10−8
cg22491058 C4BPA 1: 207277466 −0.182 −11.4 1.8 × 10−8
cg07787634 KMO 1: 241715378 −0.177 −10.3 6.7 × 10−8
cg07420362 TRPC2 11: 3647419 −0.176 −10.5 5.1 × 10−8
cg14012082 EPX 17: 56274407 −0.176 −11.9 1.0 × 10−8
cg17518550 C1orf150 1: 247712383 −0.175 −10.3 6.3 × 10−8
cg13053653 HOXD3 2: 177037631 −0.175 −11.0 2.8 × 10−8
cg08400424 ARHGAP26 5: 142357042 −0.172 −10.2 7.7 × 10−8
cg11236746 GLB1 3:33096255 −0.172 −10.5 5.4 × 10−8
cg09359351 HSPBAP1 3:122509111 −0.171 −10.1 8.1 × 10−8
cg14118850 HPCAL1 2:10447890 −0.171 −14.5 7.9 × 10−10
cg20426866 TACC2 10:123923881 −0.170 −12.1 8.6 × 10−9
cg08055663 KCTD5 16:2737356 −0.169 −10.0 9.5 × 10−8
cg08949974 RBM47 4:40632860 −0.167 −10.0 9.0 × 10−8
cg02794695 SLA; TG 8:134072611 −0.166 −10.0 9.2 × 10−8
cg11967765 GNA12 7:2774195 −0.165 −10.0 9.7 × 10−8
cg13453168 PTPRE 10:129845660 −0.165 −11.8 1.2 × 10−8
cg26933869 ALDH4A1 1:1921807 −0.164 −10.0 9.3 × 10−8
cg10111816 CDR2 16: 22384715 0.273 12.1 8.3 × 10−9
cg07852840 SPSB4 3: 140813919 0.273 11.0 2.8 × 10−8
cg17219660 GPR37L1 1: 202091880 0.269 10.7 3.9 × 10−8
cg08344351 CMIP 16: 81507328 0.269 10.0 8.8 × 10−8
cg23753807 ABR 17: 1090291 0.265 13.7 1.7 × 10−9
cg04546573 GULP1 2: 1090291 0.263 10.4 5.8 × 10−8
cg08264805 RUSC1, C1orf104 1: 155291224 0.254 13.8 1.5 × 10−9
cg17691545 SLC10A6 4: 87770586 0.254 11.6 1.4 × 19−8
cg00838040 ATP2C2 16: 84446919 0.244 11.3 2.1 × 10−8
cg13052101 MTL5 11: 68517529 0.239 11.4 1.7 × 10−8
cg10249224 TSSK3; LOC100128071 1: 32828191 0.238 11.3 2.1 × 10−8
cg09869811 NUTF2 16:67897346 0.237 13.4 2.3 × 10−9
cg14563485 ZFP14 19:36860285 0.236 11.5 1.7 × 10−8
cg02363593 DOCK2 5:169123192 0.236 11.8 1.2 × 10−8
cg18573082 PDE7B 6:136425179 0.236 12.4 6.0 × 10−9
cg15174117 CORO2B 15:68913662 0.235 11.8 1.1 × 10−8
cg05939149 PLEKHH2 2:43986106 0.235 10.6 4.4 × 10−8
cg27083087 VGLL4 3:11610239 0.234 10.6 4.4 × 10−8
cg07080653 LNX1 4:54374249 0.233 11.7 1.2 × 10−8
cg17080882 TGFBR3 1:82191625 0.232 10.6 4.8 × 10−8
  1. A positive value for ∆beta indicates hypermethylation before weight loss in comparison to after weight loss, and a negative value indicates hypomethylation.