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Figure 6 | Genome Biology

Figure 6

From: Global mRNA selection mechanisms for translation initiation

Figure 6

Functional analysis of proteins encoded by the transcript clusters. (A) Gene Ontology (GO) terms that are significantly over-represented (red) or under-represented (blue) for transcripts that are present within the four clusters defined in Figure 4. Only the GO terms that show significant differences (via a Fisher test comparing that cluster with the rest of the genome; FDR <0.01) for at least one cluster and also had differences between the clusters (Chi-square test; FDR <0.01) are depicted. The color scale represents the statistical significance of GO term enrichment or under-enrichment as measured by log10FDR. For convenience the GO term enrichment log10FDR values have been multiplied by -1. (B,C) Box and whisker plots, as in Figure 2, detailing the variation in ribosome occupancy [42] and protein abundance according to the PaxDb database [49] for the transcripts enriched with the closed loop components and 4E-BPs. A Wilcoxon rank test between pairwise transcripts sets revealed a significant difference (P < 1 × 10-7) in all cases for both plots; the only exception being between group I and group III for ribosomal occupancy, which was significant at P < 0.03.

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