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Figure 4 | Genome Biology

Figure 4

From: Global mRNA selection mechanisms for translation initiation

Figure 4

Four major clusters are apparent across the RIP-seq datasets. Heatmap derived from hierarchical clustering of the mRNA binding profiles (log2 fold changes IP/Total) of the six proteins in the study; red and blue represent over- and under-represented mRNAs, respectively. The analysis was restricted to 3,173 transcripts that were identified as over-represented or under-represented in any of the six datasets and hierarchical clustering was performed as described in the Materials and methods section. The heatmap presented contains 2,767 transcripts separated across 7 clusters that have been grouped into groups I to IV based upon similarity of the patterns of association.

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