Prediction algorithm | Accuracy (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Composite (95% CI) |
---|---|---|---|---|---|---|
CHASM (breast) | 80.13% (75.42-84.18%) | 72.34% (65.70-78.34%) | 93.58% (88.89-97.96%) | 95.10% (91.27-98.47%) | 66.23% (58.62-73.42%) | 3.2726 (3.1090-3.4151) |
CHASM (lung) | 82.49% (78.11-86.53%) | 79.26% (73.26-84.95%) | 88.07% (81.98-94.18%) | 91.98% (87.58-96.20%) | 71.11% (63.57-78.74%) | 3.3042 (3.1370-3.4665) |
CHASM (melanoma) | 81.82% (77.44-86.20%) | 86.17% (80.93-90.96%) | 74.31% (65.71-82.46%) | 85.26% (80.21-90.00%) | 75.70% (67.29-83.91%) | 3.2145 (3.0259-3.3971) |
FATHMM (cancer) | 80.13% (75.42-84.51%) | 92.02% (87.98-95.83%) | 59.63% (50.43-69.00%) | 79.72% (74.21-84.82%) | 81.25% (72.06-89.22%) | 3.1263 (2.9242-3.3078) |
FATHMM (missense) | 75.42% (70.71-79.80%) | 86.70% (81.82-91.37%) | 55.96% (46.29-64.82%) | 77.25% (71.67-82.33%) | 70.93% (60.92-80.23%) | 2.9085 (2.7014-3.1033) |
Mutation Assessor | 68.69% (63.64-73.40%) | 71.28% (64.77-77.25%) | 64.22% (54.46-72.81%) | 77.46% (71.26-82.93%) | 56.45% (47.82-64.87%) | 2.6941 (2.4757-2.8892) |
MutationTaster | 84.51% (80.13-88.55%) | 84.04% (78.53-89.25%) | 85.32% (78.18-91.75%) | 90.80% (86.05-95.00%) | 75.61% (67.42-82.88%) | 3.3578 (3.1879-3.5244) |
PolyPhen-2 | 69.36% (64.31-74.41%) | 78.72% (73.16-84.53%) | 53.21% (43.59-62.50%) | 74.37% (68.08-80.21%) | 59.18% (49.47-69.01%) | 2.6549 (2.4296-2.8672) |
PROVEAN | 58.59% (52.86-63.64%) | 51.06% (43.78-57.73%) | 71.56% (62.83-80.00%) | 75.59% (68.61-82.81%) | 45.88% (38.61-53.76%) | 2.4410 (2.2263-2.6521) |
SIFT | 69.70% (64.65-74.75%) | 81.91% (76.09-87.57%) | 48.62% (38.89-58.62%) | 73.33% (67.31-78.92%) | 60.92% (51.14-71.64%) | 2.6479 (2.4175-2.8681) |
VEST | 54.88% (49.49-60.27%) | 71.81% (65.80-77.89%) | 25.69% (18.01-34.19%) | 62.50% (56.34-68.78%) | 34.57% (24.99-45.21%) | 1.9456 (1.7302-2.1701) |
CanDrA (breast) | 61.69% (55.89-66.78%) | 97.85% (95.50-99.48%) | 0% (0-0%) | 62.54% (57.04-67.82%) | 0% (0-0%) | 1.6039 (1.5437-1.6593) |
CanDrA (lung) | 84.70% (80.50-88.65%) | 79.12% (73.21-84.57%) | 94.95% (89.81-98.94%) | 96.64% (93.29-99.31%) | 71.21% (63.41-78.30%) | 3.4193 (3.2675-3.5628) |
CanDrA (melanoma) | 82.61% (77.94-86.64%) | 78.09% (71.43-83.82%) | 90.82% (85.06-96.00%) | 93.92% (89.86-97.33%) | 69.53% (61.10-77.05%) | 3.3236 (3.1491-3.4780) |
Condel | 76.77% (72.05-81.48%) | 93.09% (89.36-96.32%) | 48.62% (39.62-58.33%) | 75.76% (70.38-81.03%) | 80.30% (70.58-89.55%) | 2.9777 (2.7814-3.1877) |