Prediction algorithm | Accuracy (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Composite (95% CI) |
---|---|---|---|---|---|---|
CHASM (breast) | 88.68% (86.55-90.70%) | 89.99% (87.81-91.92%) | 80.71% (73.33-87.12%) | 96.59% (95.20-97.73%) | 57.07% (50.23-64.58%) | 3.2436 (3.1127-3.3669) |
CHASM (lung) | 90.09% (88.27-91.81%) | 92.23% (90.40-94.04%) | 77.14% (69.93-83.58%) | 96.07% (94.74-97.31%) | 62.07% (54.72-69.38%) | 3.2751 (3.1418-3.3988) |
CHASM (melanoma) | 89.69% (87.77-91.51%) | 93.64% (92.00-95.37%) | 65.71% (57.35-73.51%) | 94.31% (92.67-95.76%) | 63.01% (55.40-70.92%) | 3.1667 (3.0181-3.3079) |
FATHMM (cancer) | 91.00% (89.18-92.62%) | 97.88% (96.87-98.82%) | 49.29% (41.08-57.24%) | 92.13% (90.26-93.72%) | 79.31% (70.59-87.66%) | 3.1860 (3.0326-3.3292) |
FATHMM (missense) | 82.51% (79.98-84.73%) | 87.75% (85.46-89.94%) | 50.71% (42.98-58.27%) | 91.52% (89.53-93.23%) | 40.57% (33.53-47.72%) | 2.7056 (2.5576-2.8521) |
Mutation Assessor | 74.70% (71.89-77.51%) | 76.65% (73.87-79.65%) | 62.86% (54.61-71.21%) | 92.59% (90.35-94.55%) | 30.77% (25.69-36.70%) | 2.6287 (2.4835-2.7842) |
MutationTaster | 88.57% (86.65-90.60%) | 90.81% (88.94-92.84%) | 75.00% (66.91-82.00%) | 95.66% (94.10-97.00%) | 57.38% (50.00-65.14%) | 3.1885 (3.0502-3.3300) |
PolyPhen-2 | 79.78% (77.05-82.11%) | 84.22% (81.83-86.61%) | 52.86% (44.51-61.15%) | 91.55% (89.45-93.40%) | 35.58% (29.44-42.16%) | 2.6420 (2.4895-2.7915) |
PROVEAN | 73.71% (70.88-76.64%) | 74.44% (71.51-77.43%) | 69.29% (61.72-76.06%) | 93.63% (91.82-95.31%) | 30.89% (25.93-36.56%) | 2.6825 (2.5505-2.8088) |
SIFT | 80.99% (78.26-83.42%) | 86.10% (83.89-88.45%) | 50.00% (41.93-58.40%) | 91.26% (89.08-93.15%) | 37.23% (30.34-44.28%) | 2.6460 (2.4895-2.7968) |
VEST | 75.03% (72.50-77.76%) | 82.69% (80.28-85.24%) | 28.57% (21.01-35.40%) | 87.53% (85.12-89.75%) | 21.39% (15.91-27.57%) | 2.2018 (2.0568-2.3395) |
CanDrA (breast) | 81.81% (79.23-84.26%) | 95.38% (93.85-96.81%) | 0% (0-0%) | 85.19% (82.83-87.30%) | 0% (0-0%) | 1.8056 (1.7765-1.8340) |
CanDrA (lung) | 91.28% (89.54-93.04%) | 92.86% (91.05-94.62%) | 80.95% (73.64-87.32%) | 96.97% (95.75-98.03%) | 63.35% (56.10-71.01%) | 3.3413 (3.2103-3.4747) |
CanDrA (melanoma) | 88.97% (87.02-90.91%) | 90.73% (88.69-92.81%) | 77.60% (69.57-84.40%) | 96.33% (94.89-97.53%) | 56.40% (48.77-63.74%) | 3.2105 (3.0705-3.3507) |
Condel | 85.84% (83.42-88.17%) | 92.58% (90.81-94.28%) | 45.00% (37.06-53.72%) | 91.08% (89.16-92.94%) | 50.00% (41.43-59.06%) | 2.7866 (2.6222-2.9552) |