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Table 1 Summary of in vivo tumourigenesis assay

From: Polygenic in vivovalidation of cancer mutations using transposons

Generation

Transposase

Transposons

Animals (n)

Animals with tumours (n)

Median tumour latency (weeks)

Animals with tumours (%)

F0 chimaeras

+

+

21

8

85.5

38

F0 chimaeras

-

+

20

3

89.9

15

F1 animals

+

+

65

44

108.4

67

F1 animals

+

+ (p53.R270H)

20

6

74.9

30