From: Polygenic in vivovalidation of cancer mutations using transposons
Generation | Transposase | Transposons | Animals (n) | Animals with tumours (n) | Median tumour latency (weeks) | Animals with tumours (%) |
---|---|---|---|---|---|---|
F0 chimaeras | + | + | 21 | 8 | 85.5 | 38 |
F0 chimaeras | - | + | 20 | 3 | 89.9 | 15 |
F1 animals | + | + | 65 | 44 | 108.4 | 67 |
F1 animals | + | + (p53.R270H) | 20 | 6 | 74.9 | 30 |