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Figure 5 | Genome Biology

Figure 5

From: Checkpoints couple transcription network oscillator dynamics to cell-cycle progression

Figure 5

Oscillating transcripts arrest with distinct behaviors during cell-cycle checkpoints. Absolute mRNA levels (arbitrary expression units) are shown for periodic genes in normally-cycling WT cells (black; left), Cdc20-depleted cells (CDK `on’) (blue; right) DNA replication checkpoint-arrested cells (cdc8ts) (red; right), and spindle assembly checkpoint-arrested cells (P GAL -cse4-353) (green; right) (a-d). mRNA levels from arrested cdc8ts cells (DNA replication checkpoint) and arrested P GAL -cse4-353 cells (spindle assembly checkpoint) were temporally aligned on the graph at the point where 50% of the synchronized population had budded. CLN2 (SBF target) (a), RNR1 (MBF target) (b), CLB2 (SFF target) (c), and SIC1 (Ace2/Swi5 target).

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