Figure 6

Two relapse patterns in a TCGA primary-relapse ovarian tumor dataset. (A) TCGA-13-0913 exemplifies a recursion pattern in which the relapse subclones are originated from multiple subclones in the primary, suggesting inadequate primary treatment. (B) TCGA-13-1817 signifies a different pattern in which one subclone in the primary acquired new mutations, became resistant to primary chemotherapy, and gave rise to the entire relapse tumor mass.