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Figure 3 | Genome Biology

Figure 3

From: Unraveling the clonal hierarchy of somatic genomic aberrations

Figure 3

Building the evolution path. (A) For each genomic segment, the uncertainty value around β is a function of the number of informative SNPs and of the mean local coverage. (B) Tumor evolution paths are built from ordered aberrations consistently observed in multiple samples. On the left, arrows indicate ordered aberrations based on clonality estimates within the same tumor; three distinct aberrations (orange, green, and blue) precede a fourth one (red). Ordered aberrations that find statistical support (as recurrent in multiple samples) contribute to the tumor evolution path (right).

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