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Figure 5 | Genome Biology

Figure 5

From: Diverse modes of genomic alteration in hepatocellular carcinoma

Figure 5

LAMA2 status is associated with clinical outcome in hepatocellular carcinoma. (A) Microarray-based expression profile of LAMA2 across a panel of cancer and normal human tissues (Gene Logic, Gaithersburg, MD, USA). Numbers at the top are -log10 P-values for a two-sided t-test comparing the expression values between the normal (green) and cancer (red) samples of the same tissue. (B) Microarray-based expression profile of LAMA2 in 300 HCC patients from University of Hong Kong (data from Gene Expression Omnibus series GSE25097). The number at the top is the -log10 P-value for a two-sided t-test comparing the expression values between the non-tumor (blue) and cancer (red) samples. (C) Kaplan-Meier curves for survival of LAMA2-low versus LAMA2-high HCC patients from a cohort of 228 HCC patients from the University of Hong Kong. Patients with low LAMA2 expression show poorer overall survival (left panel) and disease-free survival (right panel) by log-rank test (P-values of 0.024 and 0.026, respectively). HR: hazard ratio between LAMA-high and LAMA-low samples.

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