Targeted resequencing of relapse-specific mutations in diagnostic DLBCL. (A) Resequencing of UBR4 SNV (chr1:19519971, C > A) in pair 1D and 1R1. The allele frequencies of the reference sequences and the SNV in both samples 1D and 1R1 are shown. (B) Comparison of the clonal evolution pattern represented by the dominant VHDJH subclone (filled square) and the genetic evolution pattern indicated by the UBR4 SNV (filled circle) of pair 1. (C) Resequencing of B2M indel (chr15:45003781-45003782) in patient pair 9 (15D1, 15D2, and 15R). (D) Comparison of the clonal evolution pattern and the genetic evolution pattern of patient pair 9.