Figure 3
From: Genome-driven integrated classification of breast cancer validated in over 7,500 samples
Association between subtype and clinical outcome. (A) Survival plots by subtype for external studies with available time-to-event data. The METABRIC study is excluded. (B) Comparison of univariable hazard ratios (boxes) and 95% confidence intervals (vertical lines) for IntClust subtypes, taking IntClust 3 as referent, for each of three follow-up brackets (0 to 4 years, 4 to 8 years, 8 to 15 years) separately for cases in the METABRIC study and those in external studies. Box sizes are weighted according to sample size. (C) Bar-charts depicting the proportion of tumors that underwent pathological complete response (pCR) by molecular subtype in all external studies of neo-adjuvant chemotherapy.