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Figure 1 | Genome Biology

Figure 1

From: Genome-driven integrated classification of breast cancer validated in over 7,500 samples

Figure 1

Reproducible IntClust gene expression profiles enable accurate classification. (A) Cross-tabulation of IntClust subtypes classified according to the combined (copy number and gene expression) classifier and the expression-based classifier in the METABRIC validation dataset (N = 983). Intensity of box colors is proportional to the depicted value. (B) Comparison of average gene-expression profiles for all 10 IntClust groups in the METABRIC discovery set (left) and TCGA samples (right). The x-axis is genomic position and the y-axis is z-score log2-normalised gene expression level. (C) Scatter plot of the goodness of fit, number of samples and number of available features for expression-based IntClust classification by each study. GOF, goodness of fit.

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