Figure 2

Altered lncRNAs across lung cancer subtypes. (A) Expression levels of lncRNAs with known oncogenic function across three lung cohorts, denoted by different colors. The size of each point is proportional to average FPKM expression across the tumors for up-regulated lncRNAs or across the normal tissues for down-regulated lncRNAs. The x-axis shows log₂ fold change of tumor relative to normal. (B,C) Venn diagrams showing the overlap of significantly up-regulated lncRNAs (B) and down-regulated lncRNAs (C). (D) Expression levels of tumor and normal samples for each cohort across the 111 LCALs. Colored bars to the right designate in which cohort(s) a given LCAL is differentially expressed.