Metastatic tumor evolution and organoid modeling implicate TGFBR2as a cancer driver in diffuse gastric cancer

Table 1 Cancer oncogenes with amplifications or cancer drivers with biallelic events

Origin	Known or candidate cancer driver	Biallelic event	Allelic alteration 1	Mutation or genomic aberration	Chr	Chr position or interval	Allelic alteration 2
Unique to the primary	FGFR2*		Amplification	6-fold amplification	10	117820033 - 119748751
Common to the primary tumor and metastasis	CDH1	Yes	Deletion	Partial deletion of exon 9	16	68847326 - 68847403	Germline mutation in CDH1
Common to the primary tumor and metastasis	TP53	Yes	5’ splice site mutation	Aberrant splicing	17	7578370	Hemizygous loss of 17p arm
Unique to the metastasis	TGFBR2	Yes	Frameshift indel	Stop codon in exon 4	3	30691871	Hemizygous deletion of wild-type TGFBR2 locus
	PCDH7	Yes	Missense	S87R	4	30723305	Hemizygous deletion of wild-type 4 arm
	FERMT1 loci	Yes	Loss of heterozygosity	FERMT1 located in 20p12.3	20		FERMT1 mutation
	BMP7 loci	Yes	Loss of heterozygosity	BMP7 located in 20q13.3	20		BMP7 mutation

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