Figure 2

Comparison of the genetic aberrations in the primary tumor and metastasis. Common versus exclusive genetic aberrations are compared between the two tumor genomes. (a) Genes with coding mutations having a potential deleterious impact are listed. These genes are classified based on whether they are exclusive (red characters) or common (green characters) to the primary tumor and metastasis. The mutations all lead to changes in the amino acid composition of the gene product and were identified to have a significant alteration with a high likelihood of affecting the gene product function. (b) A summary of the chromosomal aberrations is shown across the entire cancer genome of both tumors. This includes copy number variation (CNV) or loss of heterozygosity (LOH). The red blocks indicates events exclusive to the primary tumor or metastasis. The green blocks indicate events common to both. The number of events per chromosome is listed in each block. Arrows indicate LOH events or deletions that encompass the p arm, q arm, or entire chromosome. Red arrows indicate chromosomal aberrations that are exclusive and green arrows indicate events that are common.