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Figure 3 | Genome Biology

Figure 3

From: MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes

Figure 3

Prediction performance on simulated data. (a) Histogram of the predicted mixing ratio from selected informative bins insimulation results when bisulfite reads of HCC and HMEC cell lines are mixed at different ratios. Dotted blue lines highlight the true minor components. Black line is the density of the predicted mixing ratio. (b, c) Predicted minor compositions (α1) at different mixing ratios where the composition of tumor cell line is above 50% (b) or below 50% (c). Error bars represent standard derivations derived from 20 mixing simulations.

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