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Natural calcineurin inhibitor

Genome Biology20034:spotlight-20030103-01

  • Published:


  • Signal Transduction
  • Transduction Pathway
  • Signal Transduction Pathway
  • Phosphatase Activity
  • Cellular Localization

FK506 is an immunosuppressive drug that inhibits the phosphatase activity of calcineurin, thereby interfering with normal signal transduction pathways. In an Advanced Online Publication in Nature Cell Biology Shirane and Nakayama from Kyushu University in Japan, describe a role for the mitochondrial FK506-binding protein 38 (FKBP38) in preventing apoptosis (Nature Cell Biology, 23 December 2002, DOI:10.1038/ncb894). They fished out FKBP38 in a yeast two-hybrid screen for Bcl-2-interacting proteins. FKBP38 co-immunoprecipitates with Bcl-2 and the related Bcl-XL protein. It also interacts with calcineurin, in a FK506-independent manner, and inhibits its phosphatase activity. FKBP38 regulates the cellular localization of Bcl-2 and Bcl-XL, targeting them to the mitochondria and preventing apoptosis.


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  4. Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs.Google Scholar


© BioMed Central Ltd 2003