Skip to main content

Advertisement

TRF2 and transcription

Article metrics

  • 387 Accesses

TRF2, TATA-box-binding protein (TBP)-related factor 2, is important for development and differentiation, but little is known about how TRF2 controls transcription and gene expression. In the November 28 Nature Hochheimer et al. demonstrate that TRF2 functions as a core-promoter selectivity factor in flies (Nature 2002, 420:439-444). Immuno-affinity purification of Drosophila TRF2-containing complexes showed that TRF2 interacts with DREF (DNA replication-related element binding factor) and several components of the NURF (nucleosome remodelling factor) chromatin-remodelling complex. TRF2 regulates the DREF-responsive promoter of the PCNA gene. Microarray analysis showed that TRF2 may direct the expression of a subset of DRE-dependent genes. Results from RNA interference experiments provided additional support for the functional interaction between TRF2 and DREF in promoter selectivity.

References

  1. 1.

    TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family.

  2. 2.

    Nature, [http://www.nature.com]

Download references

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Weitzman, J.B. TRF2 and transcription. Genome Biol 3, spotlight-20021128-01 (2002) doi:10.1186/gb-spotlight-20021128-01

Download citation

Keywords

  • Gene Expression
  • Microarray Analysis
  • Binding Factor
  • Related Factor
  • Functional Interaction