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Open Access

Strep genomics

  • Jonathan B Weitzman
Genome Biology20023:spotlight-20020403-01

https://doi.org/10.1186/gb-spotlight-20020403-01

Published: 3 April 2002

Keywords

Heart DiseaseGenome SequenceTherapeutic StrategyMicroarray AnalysisSecrete Protein

Group AStreptococcus(GAS) infection by serotype M18 strains causes acute rheumatic fever (ARF) and can lead to pediatric heart disease. In the April 2 Proceedings of the National Academy of Sciences, James Smoot and colleagues at the National Institute of Allergy and Infectious Diseases report the genome sequence of a GAS strain (MGAS8232) isolated from a patient with ARF (Proc Natl Acad Sci USA 2002, 99:4668-4673). They compared the 1.9 Mb genome with a closely related strain (the M1 serotype SF370 strain) and found 178 putative genes unique to MGAS8232. Several of these encode secreted proteins that may be important for host-GAS interactions. Microarray analysis of different serotype M18 strains revealed that much of the genetic variation was due to phage or phage-like sequence elements. Comparative GAS genomics should lead to greater understanding of ARF pathogenesis and potential therapeutic strategies.

References

  1. Pathogenesis of group A streptococcal infections.Google Scholar
  2. Proceedings of the National Academy of Sciences, [http://www.pnas.org]
  3. National Institute of Allergy and Infectious Diseases , [http://www.niaid.nih.gov]
  4. Complete genome sequence of an M1 strain of Streptococcus pyogenes.Google Scholar

Copyright

© BioMed Central Ltd 2002

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