Skip to main content

Advertisement

Matrix modulation in monocytes

Article metrics

  • 372 Accesses

The interactions of cells with the extracellular matrix (ECM) are critical for orchestrating immune and inflammatory responses. In the December Immunity, de Fougerolles et al. report a comprehensive analysis of gene expression profiles affected by the attachment of monocytes to fibronectin and other ECM components (Immunity 2000, 13:749-758). They used a quantitative, restriction enzyme-based profiling method, named GeneCalling, to examine the integrin-mediated induction of genes in the monocyte cell line THP-1. De Fougerolles et al. identified over 140 genes induced by matrix attachment, including several encoding secreted cytokine factors and cell surface receptors. ECM and growth factors synergistically activated many genes regulated by the NF-kappaB and Jak/STAT signalling pathways. Furthermore, different ECM substrates induced both distinct and overlapping gene sets. Matrix-induced genes are likely to play roles in extravasation, migration and phagocytosis by monocytic cells during the inflammatory response.

References

  1. 1.

    Adhesion receptors of the immune system.

  2. 2.

    Immunity, [http://www.immunity.com]

  3. 3.

    Gene expression analysis by transcript profiling coupled to a gene database query.

Download references

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Weitzman, J.B. Matrix modulation in monocytes. Genome Biol 2, spotlight-20010116-01 (2001) doi:10.1186/gb-spotlight-20010116-01

Download citation

Keywords

  • Signalling Pathway
  • Cell Surface
  • Inflammatory Response
  • Extracellular Matrix
  • Gene Expression Profile