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Table 4 Number of unique and shared ageCGs/genes affiliated with genes expressed within tissues a

From: Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape

 

Unique ageCGs/genesb

Shared ageCGs/genesc

P-valued

Expressed

Non-expressed

Expressed

Non-expressed

 

Blood

13 (65.0)

7 (35.0)

8 (22.9)

27 (77.1)

0.003 *

Brain

16 (72.7)

6 (27.3)

27 (75.0)

9 (25.0)

0.766

Kidney

82 (78.8)

22 (21.2)

17 (56.7)

13 (43.3)

0.019

Muscle

84 (88.4)

11 (11.6)

11 (42.3)

15 (57.7)

3.40 × 10-6 *

  1. aExpressed genes, FPKM > 0.25; non-expressed genes, FPKM < 0.05. Parentheses indicate percentage of total in each CpG context category.
  2. bUnique ageCGs/genes had q < 0.05 from linear regression results in one tissue and q > 0.5 for the same affiliated gene in the other three tissues.
  3. cShared ageCGs/genes had q < 0.05 in all four tissues.
  4. dResulting P-values from Fisher’s exact tests between the number of unique and shared, expressed or non-expressed ageCGs/genes within tissues.
  5. *Significant P-values meet Bonferroni correction for multiple testing.