Neurexins

Table 2 Interaction partners of neurexins

Protein	Binding site	Requirement for		Reference(s)
Protein	Binding site	Splice insert	Ca²⁺binding	Reference(s)
Binding partners specific for α-Nrxn:
Neurexophilin	αLNS2	-	-	[17, 19, 128]
Shared by α-Nrxn and β-Nrxn:
Neuroligin	αLNS6, βLNS	(−/+)SS#4	+	[15, 16, 54]
Dystroglycan	αLNS2, αLNS6, βLNS	-SS#2, -SS#4	+	[20]
GABA(A)R	αLNS6, βLNS	-SS#4		[8]
LRRTM	αLNS6, βLNS	-SS#4	+	[21, 22]
Cerebellin	αLNS6, βLNS	+SS#4	-	[23, 24]
Synaptotagmin	Cytosolic domain	-	+	[80]
Znf804a	Cytosolic domain	-	-	[129]
CASK	PDZ motif	-	-	[77, 78]
Mint/X11/Apba	PDZ motif	-	-	[78]
AF-6	PDZ motif	-	-	[130]

Summary of binding partners of α-neurexins and β-neurexins (Nrxn). Note that neuroligins preferentially bind to neurexins without insert in splice site 4 (−SS#4) and that binding is modified by the presence of + SS#4 as discussed in the main text. Of all currently known interaction partners only neurexophilins bind exclusively to α-neurexin [17]. Neurexophilins are expressed only in distinct neuronal populations in the brain [18, 19, 128, 131] but may modulate the function of their cognate α-neurexin receptors [18, 128]. LNS, laminin-neurexin-sex hormone binding globulin.

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