Figure 3

Lasso regression results. (a) Scatter plot of the viability scores predicted in the 'leave-one-cell-line-out' iterations for PI-103 (blue), JAK-i (red), and MEK-i (green) versus the observed ones. For comparability, all the scores were normalized in order to have zero mean, and unitary standard deviations. Predicted scores were normalized together with the training-set prediction in the corresponding iteration while observed scores were normalized drug-wisely. The inserts report average non-null coefficients and average non-null coefficient rate in the final descriptive models for PI-103 (b), JAK-i (c), and MEK-i (d) for phosphopeptides whose rate is > 50% (that is, sufficiently stably included in the optimal models).