From: Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis
Subtype | PL | PI | PH | |||
---|---|---|---|---|---|---|
 | HR (95%CI) | P -value2 | HR (95%CI) | P -value | HR (95%CI) | P -value |
ER- | n = 51 3 | n = 101 | n = 249 | |||
B/P (L, I, H)1: | 0.81 (0.33 to 2.00) | 0.65 | 0.60 (0.41 to 0.89) | 0.01 | 0.63 (0.48 to 0.83) | 0.001 |
T/NK (L, I, H): | 3.67 (1.13 to 11.9) | 0.01 | 0.54 (0.38 to 0.78) | 0.001 | 0.59 (0.44 to 0.78) | 0.0003 |
M/D (L, I, H): | 3.90 (1.28 to 11.9) | 0.003 | 0.65 (0.45 to 0.94) | 0.02 | 0.59 (0.45 to 0.78) | 0.0002 |
ER+ | n = 542 | n = 458 | n = 343 | |||
B/P (L, I, H): | 0.77 (0.56 to 1.04) | 0.09 | 1.03 (0.81 to 1.30) | 0.83 | 0.56 (0.45 to 0.69) | < 0.0001 |
T/NK (L, I, H): | 0.80 (0.59 to 1.10) | 0.17 | 0.98 (0.78 to 1.23) | 0.85 | 0.60 (0.48 to 0.73) | < 0.0001 |
M/D (L, I, H): | 0.86 (0.64 to 1.16) | 0.33 | 0.93 (0.74 to 1.18) | 0.57 | 0.59 (0.48 to 0.73) | < 0.0001 |
Basal-like | n = 40 | n = 113 | n = 307 | |||
B/P (L, I, H): | 0.97 (0.47 to 2.02) | 0.94 | 0.64 (0.43 to 0.96) | 0.03 | 0.67 (0.52 to 0.85) | 0.001 |
T/NK (L, I, H): | 1.63 (0.68 to 3.95) | 0.23 | 0.48 (0.33 to 0.69) | 0.0002 | 0.65 (0.51 to 0.83) | 0.0006 |
M/D (L, I, H): | 1.87 (0.74 to 4.72) | 0.14 | 0.54 (0.37 to 0.79) | 0.002 | 0.60 (0.47 to 0.77) | < 0.0001 |
HER2-E | n = 14 | n = 66 | n = 94 | |||
B/P (L, I, H): | 0.70 (0.17 to 2.85) | 0.62 | 0.72 (0.46 to 1.14) | 0.16 | 0.51 (0.34 to 0.78) | 0.002 |
T/NK (L, I, H): | 0.08 (0.007 to 0.9) | 0.02 | 0.79 (0.53 to 1.16) | 0.23 | 0.46 (0.31 to 0.68) | 0.0001 |
M/D (L, I, H): | 0.66 (0.24 to 1.85) | 0.43 | 0.96 (0.64 to 1.46) | 0.86 | 0.53 (0.36 to 0.78) | 0.001 |
Luminal B | n = 26 | n = 135 | n = 212 | |||
B/P (L, I, H): | 2.28 (0.82 to 6.32) | 0.11 | 0.97 (0.65 to 1.43) | 0.86 | 0.52 (0.38 to 0.71) | < 0.0001 |
T/NK (L, I, H): | 2.81 (1.06 to 7.49) | 0.03 | 0.68 (0.43 to 1.08) | 0.09 | 0.60 (0.45 to 0.80) | 0.0002 |
M/D (L, I, H): | 2.23 (0.83 to 5.96) | 0.11 | 0.50 (0.30 to 0.83) | 0.003 | 0.57 (0.42 to 0.77) | < 0.0001 |
Luminal A | n = 347 | n = 200 | n = 20 | |||
B/P (L, I, H): | 0.71 (0.44 to 1.13) | 0.14 | 0.95 (0.58 to 1.56) | 0.83 | 1.41 (0.52 to 3.86) | 0.50 |
T/NK (L, I, H): | 0.57 (0.33 to 0.97) | 0.03 | 1.08 (0.68 to 1.72) | 0.73 | 0.98 (0.34 to 2.79) | 0.96 |
M/D (L, I, H): | 0.70 (0.44 to 1.12) | 0.13 | 1.10 (0.71 to 1.71) | 0.66 | 1.45 (0.44 to 4.79) | 0.55 |
Claudin-Low | n = 31 | n = 22 | n = 39 | |||
B/P (L, I, H): | 2.1 (0.53 to 8.00) | 0.24 | 1.5 (0.59 to 3.79) | 0.38 | 1.06 (0.56 to 2.03) | 0.85 |
T/NK (L, I, H): | > 100 (0.00 to +inf) | 0.02 | 0.70 (0.28 to 1.74) | 0.45 | 0.87 (0.44 to 1.73) | 0.69 |
M/D (L, I, H): | > 100 (0.00 to +inf) | 0.05 | 0.63 (0.24 to 1.63) | 0.36 | 0.78 (0.43 to 1.44) | 0.44 |