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Figure 2 | Genome Biology

Figure 2

From: Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

Figure 2

H3K27me3 redistribution in hypomethylated cells is associated with DNA methylation pattern. (A) Density plots showing the methylation of CpGs in Dnmt1+/+ (upper) and Dnmt1-/- (lower) MEFs. The methylation is plotted for all CpGs, CpGs within H3K27me3 down regions and H3K27me3 up regions defined by ChIP-seq. (B) Bisulfite sequencing of selected H3K27me3 down and H3K27me3 up regions in Dnmt1+/+ and Dnmt1-/- MEFs. Filled circles (black) represent 5mCpG and open circles represent CpG. Gaps indicate inconclusive base calling at a CpG site. The overall amount of 5mCpG as a percentage of total CpG in each amplicon is shown adjacent to each image. H3K27me3 down regions represent proximal promoter regions while H3K27me3 up regions represent intragenic or intergenic regions.

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Genome Biology

ISSN: 1474-760X

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