Figure 4
From: Chromosome territories reposition during DNA damage-repair response
Repositioning of chromosomes following DNA damage. Cells were treated with varying doses of cisplatin (as indicated) for 4 hours. (A, B, C, D) 2D-FISH images. Histogram distributions for chromosomes 19 (A’, B’, C’, D’) and 11 (A”, B”, C”, D”). Cells were treated with 25 μM cisplatin for varying time points (as indicated). (E, F, G, H, I) 2D-FISH images. Histogram distribution for chromosomes 19 (E’, F’, G’, H’, I’) and 11 (E”, F”, G”, H”, I”). * indicates P = 0.05. (J) and (K): TUNEL and γH2AX positive nuclei, under similar conditions. Scale bar: 10 μm.