Skip to main content
Figure 2 | Genome Biology

Figure 2

From: A computational framework for boosting confidence in high-throughput protein-protein interaction datasets

Figure 2

Flowchart of Coev2Net. Left: Markov chain Monte Carlo (MCMC) sampling to generate synthetic homologous sequences for each complex template. Right: 1) for given query protein pairs, the best template (from the structural library) is identified by protein threading; 2) structural and sequence features are extracted from the interfacial alignment and residue correlations scored with respect to the profile PGM; and 3) a classifier gives the probability of interaction for the query protein pair.

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us