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Table 4 Mean allele balances of heterozygous SNVs genome-wide and in CTRs

From: Comparison of solution-based exome capture methods for next generation sequencing

  

Control I

Additional samples

 

Exome capture method

Number of samples

Genome-widea

CTRb

Genome-widea

CTRb

Student's t-test Pc

Agilent SureSelect

3

0.517

0.524

0.511

0.517

0.007

Agilent SureSelect 50 Mb

3

0.515

0.520

0.514

0.519

0.003

NimbleGen SeqCap

20

0.516

0.527

0.514

0.523

7.1 × 10-15

NimbleGen SeqCap v2.0

3

0.512

0.518

0.514

0.519

0.013

  1. aAll called heterozygous SNVs with minimum sequencing coverage of 20×, regardless of target region. bHeterozygous SNVs with minimum sequencing coverage of 20× called within the CTRs. cStudent's t-test P-value for the difference between CTR and all sequenced regions given for the combined sample set of the control I sample and 25 additional samples.