Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma

Table 5 Presence of genes in Trichoderma known to be required in N. crassa for repeat-induced point mutation

N. crassa protein ^a	Accession number^a	Function^a	Trichodermaorthologue (ID number)
			T. atroviride	T. virens	T. reesei
RIP
RID	XP_959047.1	Putative DMT, essential for RIP and for MIP
Dim-5	XP_957479.2	Histone 3-K9 HMT essential for RIP; RdRP	152017	55211	515216
Quelling
QDE-1	XP_959047.1	RdRP, essential for quelling	361	64774	67742
QDE-2	XP_960365.2	Argonaute-like protein, essential for quelling	79413	20883	49832
QDE-3	XP_964030.2	RecQ helicase, essential for quelling	91316	30057	102458
DCL1	XP_961898.1	Dicer-like protein, involved in quelling	20162	20212	69494
DCL2	XP_963538.2	Dicer-like protein, involved in quelling	318	47151	79823
QIP	CAP68960.1	Putative exonuclease protein, involved in quelling	14588	41043	57424
MSUD
SAD-1	XP_964248.2	RdRP essential for MSUD	465	28428	103470
SAD-2	XP_961084.1	Essential for MSUD	No	No	No

^aN. crassa gene information and abbreviations taken from [36]. DMT, cytosine DNA methyltransferase; HMT, histone methyltransferase; MIP, methylation induced premeotically; MSUD, meiotic silencing of unpaired DNA; RdRP, RNA-dependent RNA-polymerase.

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