Skip to main content
Figure 6 | Genome Biology

Figure 6

From: A quantitative literature-curated gold standard for kinase-substrate pairs

Figure 6

Functional classification of kinases in the gold standard based on target overlap. Cytoscape edge-weighted force-directed diagram plots the correlation of kinases curated in the KID gold standard (nodes), based on similarity of their targets (depicted as edges corresponding to correlation scores). Kinases that have multiple overlapping targets are more correlated and cluster together in the network. Spatial organization of the nodes in the network classifies kinases based on their shared interaction profile. P-values indicate enrichment of Gene Ontology function using FunSpec [41]. Nodes in the same functional group are depicted as similar colors. Blue nodes represent correlated kinases that do not fall into any functional class. Of the 87 kinases present in the gold-standard kinase-substrate pairs, 71 share at least one target with one or more kinases. HOG, high osmolarity glycerol.

Back to article page