Figure 2

Cullin protein domain organization in humans. Cullin repeat 1 (CR1) anchors the cognate adaptor proteins, and the cullin homology domain (CH) at the carboxyl terminus is critical for binding of the RING-finger protein. The red line indicates the position of the neddylation site. For CUL7 and PARC the neddylation site is based on consensus sequence alignment without experimental verification. Size and location of the individual domains are schematic representations and do not depict the exact proportions. Abbreviations: aa, amino acids; CH, cullin homology domain; CPH, conserved domain in CUL7, PARC and HERC2; CR, cullin repeat; DOC, a domain similar to the DOC1 domain of the anaphase-promoting complex/cyclosome but of unknown function; IBR, in between RING; RING, really interesting new gene.