Figure 2
From: What does biologically meaningful mean? A perspective on gene regulatory network validation
The regulatory effect of a TF on a target gene can be masked when the TF is mutated (loss of function) or when its levels are reduced by RNAi. Two mechanisms that explain such masking are (a) TF redundancy and (b,c) the combinatorial interactions between multiple TFs, either from (b) one family or (c) from different families. In any of these cases, loss of a single TF would have only modest effects on target gene expression. Similar shapes with different colors indicate members of the same TF family; different shapes indicate members of different TF families.