Figure 5From: Studies on Xenopus laevisintestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adultRegulated genes can be grouped into six clusters based on developmental regulation patterns. The number of genes in each cluster is indicated in the schematic diagram. (a, b) Clusters 1 and 2 represent genes that are predominantly regulated at metamorphic climax, with the former following the endogenous T3 concentration. (c, d) Clusters 3 and 4 include genes with higher levels of expression in tadpoles and frogs (larval- and adult-enriched genes), respectively. (e, f) Clusters 5 and 6 are genes up- or down-regulated mainly at stage 58. All clusters were evaluated by GO analysis and two or more examples of the significantly regulated GO categories that had >60 genes (clusters 1 and 2) and >5 genes (clusters 3 to 6) regulated during metamorphosis are listed. A complete list of GO categories associated with each cluster is listed in Table S6 in Additional file 1. PCA: principal component analysis.Back to article page