Figure 2

U-net classes and their interactions. The graph represents the Ub pathway wherein individual nodes have been collapsed into their respective general protein classes. The different contributions of (a) protein-protein and (b) genetic interactions that contribute to the overall U-net are shown separately. The proteome represents the rest of the proteome (that is, minus the Ub-system). The U-net-spec connections are shown in green while those to the proteome are shown in mauve. The intra-proteasomal protein-protein interactions are seen to stand out in graph. The figure also implies that only a fraction of the modifications are reversed by the DUBs.